Effect of fractions from Carissa edulis (Forssk.) Vahl (Apocynaceae) leaves on hypertension induced in Wistars rats

High blood pressure is an important health problem because of its prevalence and several complications. The high cost management the side effects conventional drugs have led patients to use medicinal plants. Carissa edulis one plants used in traditional hypertension. aim this study was determine crude extract fractions L-NAME hypertension rats models. phytochemical analysis extracts carried out by using thin layer chromatography method. pharmacological effect evaluated Wistar rendered hypertensive administering N (ω) -Nitro-L-Arginine-Methyl Ester (L-NAME). administered at 500 mg / kg (b/w) 20 (b/w). Blood measured a non-invasive Four were obtained after fractionation. Many chemical compounds detected diversely distributed either or fractions. aqueous induced significant decrease from 137, 00 ± 8,01 mmHg 94,75 2.84 mmHg. In other hand, only fraction exerted highest reducing 137,00 93,5±8,54